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CS-W001157 4
Total: USD 88.00

O-(4-(Trifluoromethyl)benzyl)hydroxylamine hydrochloride

  • CAS No. 321574-29-2

  • Cat. No. CS-0041896
  • Purity≥98%
  • MDL No.MFCD00231881

*For research and further manufacturing use only, not for direct human use.

O-(4-(Trifluoromethyl)benzyl)hydroxylamine hydrochloride|CS-0041896

Structure of 321574-29-2

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General Information

  • CAS No. 321574-29-2
  • Cat. No. CS-0041896
  • Purity ≥98%
  • MDL No. MFCD00231881
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉ClF₃NO
  • Molecular Weight 227.61
  • Synonym(s) O-[4-(Trifluoromethyl)benzyl]hydroxylamine hydrochloride
  • SMILES Cl.NOCC1=CC=C(C=C1)C(F)(F)F

Description

O-(4-(Trifluoromethyl)benzyl)hydroxylamine hydrochloride features a trifluoromethyl-substituted benzyl linker that imparts enhanced lipophilicity and metabolic stability. The hydroxylamine moiety enables efficient oxime formation under mild conditions, while the hydrochloride salt ensures excellent solubility and handling convenience in aqueous reaction systems.

Application

O-(4-(Trifluoromethyl)benzyl)hydroxylamine hydrochloride serves as a stable, bench-ready building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its trifluoromethyl-substituted benzyl ether functionality enables selective transformations in late-stage functionalization, while the hydroxylamine moiety facilitates oxime formation, cyclizations, and metal-catalyzed coupling reactions. The hydrochloride salt enhances solubility and handling, supporting efficient purification and scalability in synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1325
Class : 4.1
Packing Group : Ⅱ
Hazard Statements : H228-H315-H319
Precautionary Statements : P210-P240-P241-P264-P280-P302+P352-P362+P364-P370+P378

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   2.5175
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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