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CS-W001157 4
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(R)-1-(3,5-Difluorophenyl)ethanamine hydrochloride

  • CAS No. 321318-28-9

  • Cat. No. CS-0042545
  • Purity≥98%
  • MDL No.MFCD11101200

*For research and further manufacturing use only, not for direct human use.

(R)-1-(3,5-Difluorophenyl)ethanamine hydrochloride|CS-0042545

Structure of 321318-28-9

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General Information

  • CAS No. 321318-28-9
  • Cat. No. CS-0042545
  • Purity ≥98%
  • MDL No. MFCD11101200
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀ClF₂N
  • Molecular Weight 193.62
  • Synonym(s) (R)-1-(3,5-DIFLUOROPHENYL)ETHANAMINE-HCl
  • SMILES C[C@@H](N)C1=CC(F)=CC(F)=C1.[H]Cl

Description

(R)-1-(3,5-Difluorophenyl)ethanamine hydrochloride is a chiral amine featuring a sterically compact ethyl backbone and electron-deficient aromatic ring. This bench-stable derivative enables direct incorporation into asymmetric synthesis workflows, offering enhanced solubility in common organic solvents and compatibility with standard amine protection strategies.

Application

(R)-1-(3,5-Difluorophenyl)ethanamine hydrochloride serves as a chiral building block for pharmaceutical intermediates, enabling stereoselective synthesis of bioactive molecules. Its bench-stable hydrochloride salt form facilitates handling and purification, while the 3,5-difluorophenyl group provides enhanced metabolic stability and modulated lipophilicity. The compound functions effectively in amine coupling reactions, reductive amination, and as a precursor in heterocyclic scaffold construction.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.4063
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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