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N-Methylpyrazin-2-amine

  • CAS No. 32111-28-7

  • Cat. No. CS-0038033
  • Purity≥96%
  • MDL No.MFCD08456680

*For research and further manufacturing use only, not for direct human use.

N-Methylpyrazin-2-amine|CS-0038033

Structure of 32111-28-7

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General Information

  • CAS No. 32111-28-7
  • Cat. No. CS-0038033
  • Purity ≥96%
  • MDL No. MFCD08456680
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇N₃
  • Molecular Weight 109.13
  • Synonym(s) N-Methyl-2-pyrazinamine
  • SMILES CNC1=CN=CC=N1

Description

N-Methylpyrazin-2-amine features a pyrazine core with a methylated amine at the 2-position, delivering enhanced solubility and metabolic stability. This nitrogen-rich heterocycle integrates readily into pharmaceutical scaffolds and serves as a key building block in medicinal chemistry for targeted ligand design.

Application

N-Methylpyrazin-2-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to pyrazine-based scaffolds through standard functionalization. Its methylated nitrogen enhances solubility and metabolic stability while maintaining reactivity for palladium-catalyzed cross-couplings. The compound exhibits bench-stable handling and facilitates rapid diversification via nucleophilic substitution or further alkylation, making it well-suited for high-throughput synthesis of API candidates.

Synthesis

  • Route1
    • In-stock
      Chloropyrazine|CS-W018537
      14508-49-7
    • null|null
      74-89-5
    • ~99%
    • In-stock
      N-Methylpyrazin-2-amine|CS-0038033
      32111-28-7

    References

    • Alcon, Inc. Patent: US2006/142307 A1, 2006 ; Location in patent: Page/Page column 5; 16 ; US 20060142307 A1
  • Route2

    References

    • US2003/69284 A1, ; US 20030069284 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.81
  • LogP   0.5183
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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