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3-(2-methoxyethoxy)prop-1-yne

  • CAS No. 31995-08-1

  • Cat. No. CS-0038923
  • Purity≥95%
  • MDL No.MFCD13192005

*For research and further manufacturing use only, not for direct human use.

3-(2-methoxyethoxy)prop-1-yne|CS-0038923

Structure of 31995-08-1

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General Information

  • CAS No. 31995-08-1
  • Cat. No. CS-0038923
  • Purity ≥95%
  • MDL No. MFCD13192005
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₀O₂
  • Molecular Weight 114.14
  • Synonym(s) 3-(2-Methoxy-ethoxy)propyne
  • SMILES C#CCOCCOC

Description

3-(2-Methoxyethoxy)prop-1-yne is a bench-stable alkyne reagent featuring a polar ether side chain that enhances solubility in aqueous and mixed organic solvents. This functionality enables efficient coupling in copper-catalyzed click reactions, particularly in bioconjugation workflows where solubility and stability are critical.

Application

3-(2-Methoxyethoxy)prop-1-yne serves as a versatile terminal alkyne building block for copper-catalyzed azide-alkyne cycloaddition (CuAAC) and other transition-metal-mediated coupling reactions. Its ether-stabilized alkyne functionality offers enhanced bench stability and compatibility with diverse functional groups, enabling efficient incorporation into complex molecular architectures. The pendant methoxyethoxy chain improves solubility in polar organic solvents and facilitates purification by chromatography.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 3271
Class : 3
Packing Group : Ⅲ
Hazard Statements : H225
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P370+P378-P501

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   0.2826
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   4

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