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CS-W001157 4
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4-(1-(tert-Butoxycarbonyl)piperidin-3-yl)butanoicacid

  • CAS No. 318536-95-7

  • Cat. No. CS-0171778
  • Molecule weight271.35
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(1-(tert-Butoxycarbonyl)piperidin-3-yl)butanoicacid|CS-0171778

Structure of 318536-95-7

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General Information

  • CAS No. 318536-95-7
  • Cat. No. CS-0171778
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₅NO₄
  • Molecular Weight 271.35
  • Synonym(s) 4-(1-Boc-piperidin-3-yl)-butyric acid
  • SMILES CC(C)(C)OC(=O)N1CCCC(CCCC(=O)O)C1

Description

This piperidine-based building block features a tert-butoxycarbonyl-protected amine and a pendant butanoic acid, enabling straightforward functionalization in peptide and macrocycle synthesis. The Boc group offers stability during handling, while the carboxylic acid facilitates coupling reactions under standard conditions.

Application

4-(1-(tert-Butoxycarbonyl)piperidin-3-yl)butanoic acid serves as a versatile building block for the synthesis of bioactive piperidine-containing scaffolds. The tert-butyl ester group provides excellent bench stability and facilitates orthogonal deprotection, while the pendant carboxylic acid enables facile coupling reactions. This structure functions effectively in peptide and small-molecule conjugation workflows, offering reliable access to diverse heterocyclic architectures relevant to medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   2.8884
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   4

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