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CS-W001157 4
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3-Carboxymethylpiperidine-1-carboxylic acid tert-butyl ester

  • CAS No. 183483-09-2

  • Cat. No. CS-W000209
  • Purity≥96%
  • MDL No.MFCD02178999

*For research and further manufacturing use only, not for direct human use.

3-Carboxymethylpiperidine-1-carboxylic acid tert-butyl ester|CS-W000209

Structure of 183483-09-2

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General Information

  • CAS No. 183483-09-2
  • Cat. No. CS-W000209
  • Purity ≥96%
  • MDL No. MFCD02178999
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₁NO₄
  • Molecular Weight 243.30
  • Synonym(s) 1-Boc-piperidine-3-acetic acid
  • SMILES O=C(O)CC1CN(C(OC(C)(C)C)=O)CCC1

Description

This tert-butyl ester derivative delivers a protected piperidine scaffold with orthogonal functionality, enabling seamless incorporation into peptide macrocyclization and medicinal chemistry campaigns. The carboxymethyl and carboxylic acid groups provide strategic handles for conjugation and derivatization under standard conditions.

Application

3-Carboxymethylpiperidine-1-carboxylic acid tert-butyl ester serves as a versatile building block for medicinal chemistry and peptide-like scaffold synthesis. Its orthogonal protection scheme enables selective deprotection and functionalization, while the tert-butyl ester group offers excellent bench stability and compatibility with standard coupling conditions. The molecule facilitates efficient access to piperidine-based heterocycles and functionalized amine intermediates via mild acidic cleavage or reductive methods.

Synthesis

  • Route1

    References

    • European Journal of Medicinal Chemistry, , vol. 34, # 5 p. 363 - 380
  • Route2

    References

    • European Journal of Medicinal Chemistry, , vol. 34, # 5 p. 363 - 380

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   2.1082
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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