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CS-W001157 4
Total: USD 88.00

3-(Dibenzylamino)propan-1-ol

  • CAS No. 3161-51-1

  • Cat. No. CS-0156315
  • Purity≥97%
  • MDL No.MFCD00075550

*For research and further manufacturing use only, not for direct human use.

3-(Dibenzylamino)propan-1-ol|CS-0156315

Structure of 3161-51-1

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General Information

  • CAS No. 3161-51-1
  • Cat. No. CS-0156315
  • Purity ≥97%
  • MDL No. MFCD00075550
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₂₁NO
  • Molecular Weight 255.36
  • Synonym(s) 3-(Dibenzylamino)-1-propanol
  • SMILES C1=CC=C(C=C1)CN(CCCO)CC2=CC=CC=C2

Description

3-(Dibenzylamino)propan-1-ol features a tertiary amine center flanked by two benzyl groups, delivering enhanced solubility and nucleophilicity. This polar, bench-stable scaffold integrates readily into synthetic pathways requiring nitrogen-rich linkers, particularly in medicinal chemistry and ligand design.

Application

3-(Dibenzylamino)propan-1-ol serves as a versatile bifunctional building block for medicinal chemistry and catalyst design, enabling efficient construction of amino-alcohol scaffolds. Its dibenzylamino group offers robust nitrogen protection with facile deprotection under standard conditions, while the primary alcohol facilitates derivatization via esterification, etherification, or coupling reactions. The molecule exhibits excellent bench stability and solubility in common organic solvents, supporting straightforward purification and integration into multi-step syntheses.

Synthesis

  • Route1
    • null|null
      128017-04-9
    • ~88%
    • In-stock
      3-(Dibenzylamino)propan-1-ol|CS-0156315
      3161-51-1

    References

    • Alberola, Angel; Alvarez, M. Angeles; Andres, Celia; Gonzalez, Alfonso; Pedrosa, Rafael Synthesis, 1990 , # 2 p. 153 - 156
  • Route2
    • null|null
      100-39-0
    • In-stock
      3-Aminopropan-1-ol|CS-W020089
      156-87-6
    • ~92%
    • In-stock
      3-(Dibenzylamino)propan-1-ol|CS-0156315
      3161-51-1

    References

    • Almiento, Giosue M.; Balducci, Daniele; Bottoni, Andrea; Calvaresi, Matteo; Porzi, Gianni Tetrahedron Asymmetry, 2007 , vol. 18, # 22 p. 2695 - 2711
  • Route3
    • null|null
      100-52-7
    • In-stock
      3-Aminopropan-1-ol|CS-W020089
      156-87-6
    • ~85%
    • In-stock
      3-(Dibenzylamino)propan-1-ol|CS-0156315
      3161-51-1

    References

    • Kawase, Yasushi; Yamagishi, Takehiro; Kutsuma, Teruo; Kataoka, Tadashi; Ueda, Kimio; Iwakuma, Takeo; Nakata, Tadashi; Yokomatsu, Tsutomu Synthesis, 2010 , # 10 art. no. F01410SS, p. 1673 - 1677

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   23.47
  • LogP   3.0712
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   7

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