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Methyl 2-formamidoacetate

  • CAS No. 3154-54-9

  • Cat. No. CS-0187476
  • Purity≥97%
  • MDL No.MFCD00037081

*For research and further manufacturing use only, not for direct human use.

Methyl 2-formamidoacetate|CS-0187476

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General Information

  • CAS No. 3154-54-9
  • Cat. No. CS-0187476
  • Purity ≥97%
  • MDL No. MFCD00037081
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₇NO₃
  • Molecular Weight 117.10
  • Synonym(s) None
  • SMILES COC(CNC=O)=O

Description

Methyl 2-formamidoacetate features a formamido group directly attached to an acetyl carbon, enabling direct incorporation into peptide-like scaffolds. This reactive ester integrates readily under mild conditions, offering a stable, moisture-tolerant platform for building bioactive heterocycles and functionalized intermediates in medicinal chemistry workflows.

Application

Methyl 2-formamidoacetate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to β-amino acid derivatives and heterocyclic scaffolds. Its formamide functionality offers orthogonal reactivity for selective transformations, while the ester group facilitates straightforward manipulation under standard conditions. The compound exhibits good bench stability and is compatible with a range of functional groups, making it well-suited for multistep synthesis and process development in medicinal chemistry workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.4
  • LogP   -1.0946
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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