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CS-W001157 4
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(6-Fluoropyridin-2-yl)-methanol

  • CAS No. 315180-17-7

  • Cat. No. CS-W006285
  • Purity≥96%
  • MDL No.MFCD07783827

*For research and further manufacturing use only, not for direct human use.

(6-Fluoropyridin-2-yl)-methanol|CS-W006285

Structure of 315180-17-7

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General Information

  • CAS No. 315180-17-7
  • Cat. No. CS-W006285
  • Purity ≥96%
  • MDL No. MFCD07783827
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆FNO
  • Molecular Weight 127.12
  • Synonym(s) 2-Fluoro-6-hydroxymethyl pyridine
  • SMILES OCC1=NC(F)=CC=C1

Description

This bench-stable (6-fluoropyridin-2-yl)methanol features a fluorinated pyridine ring paired with a reactive hydroxymethyl group, enabling direct functionalization in synthetic transformations. The electron-deficient heterocycle enhances regioselectivity in cross-coupling reactions, while the primary alcohol facilitates derivatization under mild conditions.

Application

(6-Fluoropyridin-2-yl)-methanol serves as a versatile building block in medicinal chemistry, enabling efficient incorporation of fluorinated pyridine motifs into target molecules. Its benzylic alcohol functionality facilitates straightforward derivatization via oxidation, etherification, or coupling reactions. The compound exhibits good bench stability and functional group tolerance, supporting its use in multi-step syntheses and heterocycle elaboration.

Synthesis

  • Route1
    • 2-(Chloromethyl)-6-fluoropyridine|CS-0695927
      315180-16-6
    • ~%
    • In-stock
      (6-Fluoropyridin-2-yl)-methanol|CS-W006285
      315180-17-7

    References

    • Journal of Organic Chemistry, , vol. 65, # 23 p. 7718 - 7722
  • Route2

    References

    • Journal of Organic Chemistry, , vol. 65, # 23 p. 7718 - 7722
  • Route3

    References

    • Synthesis, , # 4 p. 538 - 542

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   0.713
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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