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CS-W001157 4
Total: USD 88.00

2-Hydroxy-6-methoxybenzoic acid

  • CAS No. 3147-64-6

  • Cat. No. CS-W017816
  • Molecule weight168.15
  • Purity≥98%
  • MDL No.MFCD00674090

*For research and further manufacturing use only, not for direct human use.

2-Hydroxy-6-methoxybenzoic acid|CS-W017816

Structure of 3147-64-6

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General Information

  • CAS No. 3147-64-6
  • Cat. No. CS-W017816
  • Purity ≥98%
  • MDL No. MFCD00674090
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈O₄
  • Molecular Weight 168.15
  • Synonym(s) 6-Methoxysalicylic acid
  • SMILES COC1=CC=CC(O)=C1C(O)=O

Description

2-Hydroxy-6-methoxybenzoic acid features a strategically positioned hydroxyl group adjacent to a methoxy-substituted aromatic ring, enabling enhanced solubility and stability in polar solvents. This ortho-hydroxy substitution facilitates chelation with metal ions and supports efficient coupling reactions in synthetic workflows.

Application

2-Hydroxy-6-methoxybenzoic acid serves as a versatile building block for bioactive heterocycles and pharmaceutical intermediates. Its ortho-hydroxyl and para-methoxy groups enable facile derivatization via esterification, amidation, and electrophilic substitution. The compound exhibits good bench stability and facilitates purification by recrystallization, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.

Synthesis

  • Route1
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      30778-86-0
    • null|null
      124-38-9
    • ~72%
    • In-stock
      2-Hydroxy-6-methoxybenzoic acid|CS-W017816
      3147-64-6

    References

    • Kuehnert, Sven M; Maier, Martin E Organic letters, 2002 , vol. 4, # 4 p. 643 - 646
  • Route2

    References

    • Kung; Kasliwal; Pan; Mach; Guo Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 1039 - 1043
  • Route3

    References

    • Lamotte; Demerseman; Royer; et al. European Journal of Medicinal Chemistry, 1986 , vol. 21, # 5 p. 379 - 383

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   66.76
  • LogP   1.099
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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