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CS-W001157 4
Total: USD 88.00

4-(4-Methoxyphenoxy)aniline

  • CAS No. 31465-36-8

  • Cat. No. CS-0150373
  • Purity≥98%
  • MDL No.MFCD00044105

*For research and further manufacturing use only, not for direct human use.

4-(4-Methoxyphenoxy)aniline|CS-0150373

Structure of 31465-36-8

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General Information

  • CAS No. 31465-36-8
  • Cat. No. CS-0150373
  • Purity ≥98%
  • MDL No. MFCD00044105
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₃NO₂
  • Molecular Weight 215.25
  • Synonym(s) 4-(4-Methoxy-phenoxy)-anilin
  • SMILES COC1=CC=C(C=C1)OC2=CC=C(C=C2)N

Description

4-(4-Methoxyphenoxy)aniline features a phenolic ether linkage that enhances solubility and stability in organic media. This aniline derivative integrates readily into polymer backbones and serves as a key intermediate in the synthesis of advanced functional materials, particularly those requiring extended conjugation and thermal resilience.

Application

4-(4-Methoxyphenoxy)aniline serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and aromatic scaffolds. Its dual functionality—phenolic ether and primary amine—supports diverse coupling reactions and derivatization pathways. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns and scale-up applications.

Synthesis

  • Route1
    • 1-Methoxy-4-(4-nitrophenoxy)benzene|CS-0326768
      6337-24-2
    • ~99%
    • In-stock
      4-(4-Methoxyphenoxy)aniline|CS-0150373
      31465-36-8

    References

    • Bayer Pharmaceuticals Corp. Patent: EP1042305 B1, 2005 ; Location in patent: Page/Page column 27 ;
  • Route2

    References

    • Chemical Communications, , # 19 p. 2486 - 2488
  • Route3

    References

    • Chemical Communications, , # 19 p. 2486 - 2488

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   44.48
  • LogP   3.0697
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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