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CS-W001157 4
Total: USD 88.00

4-Chloro-2-(trifluoromethyl)phenylboronic acid

  • CAS No. 313545-41-4

  • Cat. No. CS-W013060
  • Purity≥98%
  • MDL No.MFCD04973086

*For research and further manufacturing use only, not for direct human use.

4-Chloro-2-(trifluoromethyl)phenylboronic acid|CS-W013060

Structure of 313545-41-4

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General Information

  • CAS No. 313545-41-4
  • Cat. No. CS-W013060
  • Purity ≥98%
  • MDL No. MFCD04973086
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BClF₃O₂
  • Molecular Weight 224.37
  • Synonym(s) 4-Chloro-2-(trifluoromethyl)phenyl boronic acid; 4-Chloro-2-(trifluoromethyl)phenylboronic acid
  • SMILES OB(O)C1=C(C=C(Cl)C=C1)C(F)(F)F

Description

4-Chloro-2-(trifluoromethyl)phenylboronic acid features a trifluoromethyl group that enhances electron deficiency and metabolic stability, while the chloro substituent enables downstream functionalization via cross-coupling. This bench-stable boronic acid integrates efficiently into Suzuki-Miyaura reactions, delivering arylated products with high fidelity under standard conditions.

Application

4-Chloro-2-(trifluoromethyl)phenylboronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation with aryl and vinyl halides. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the boronic acid functionality offers excellent bench stability and compatibility with diverse reaction conditions. Its orthogonal reactivity profile facilitates late-stage functionalization in complex molecule synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   1.0386
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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