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CS-W001157 4
Total: USD 88.00

3-Chloroazetidine hydrochloride

  • CAS No. 313468-63-2

  • Cat. No. CS-0051403
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Chloroazetidine hydrochloride|CS-0051403

Structure of 313468-63-2

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General Information

  • CAS No. 313468-63-2
  • Cat. No. CS-0051403
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₇Cl₂N
  • Molecular Weight 128.00
  • Synonym(s) 3-Chloro-azetidine HCl
  • SMILES Cl.ClC1CNC1

Description

3-Chloroazetidine hydrochloride is a strained, electron-deficient heterocycle enabling direct functionalization in late-stage synthesis. This bench-stable crystalline solid features high reactivity at the azetidine ring due to angle strain and the chlorine substituent. It serves as a key building block for bioactive molecules, particularly in medicinal chemistry where its ability to integrate into complex scaffolds enhances target engagement.

Application

3-Chloroazetidine hydrochloride serves as a versatile, bench-stable building block for the synthesis of bioactive heterocycles. Its strained four-membered ring enables efficient functionalization and facilitates rapid access to azetidinyl motifs prevalent in medicinal chemistry. The chloride group provides a reliable handle for nucleophilic substitution, enabling diversification via coupling reactions with amines, thiols, and other nucleophiles under mild conditions. This reagent functions effectively in standard synthetic workflows, offering high regioselectivity and compatibility with diverse protecting groups.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   0.6188
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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