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CS-W001157 4
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(3-Fluoropyridin-2-yl)methanamine dihydrochloride

  • CAS No. 312904-49-7

  • Cat. No. CS-0047058
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(3-Fluoropyridin-2-yl)methanamine dihydrochloride|CS-0047058

Structure of 312904-49-7

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General Information

  • CAS No. 312904-49-7
  • Cat. No. CS-0047058
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉Cl₂FN₂
  • Molecular Weight 199.05
  • Synonym(s) C-(3-FLUOROPYRIDIN-2-YL)-METHAMINE HYDROCHLORIDE
  • SMILES FC1=CC=CN=C1CN.Cl.Cl

Description

This bench-stable dihydrochloride salt features a fluorinated pyridine core paired with a primary amine functionality, enabling efficient coupling in medicinal chemistry. The para-fluorine substitution enhances electrophilic reactivity, while the protonated amine ensures solubility and compatibility in aqueous reaction media.

Application

(3-Fluoropyridin-2-yl)methanamine dihydrochloride serves as a versatile building block in medicinal chemistry, enabling the construction of fluorinated pyridine-containing scaffolds prevalent in kinase inhibitors and CNS-active compounds. The dihydrochloride salt enhances solubility and stability for handling, while the primary amine functionality facilitates straightforward coupling reactions, reductive amination, and amide bond formation under standard conditions. Its ortho-fluoro substitution pattern supports directed metalation and selective functionalization, making it a practical choice for iterative synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.523
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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