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CS-W001157 4
Total: USD 88.00

3,5-Dichloropyrazine-2-carboxamide

  • CAS No. 312736-50-8

  • Cat. No. CS-W019159
  • Purity≥97%
  • MDL No.MFCD10000837
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3,5-Dichloropyrazine-2-carboxamide|CS-W019159

Structure of 312736-50-8

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Description

3,5-Dichloropyrazine-2-carboxamide features a chlorinated pyrazine core with a carboxamide group at the 2-position, delivering enhanced stability and tunable reactivity. This electron-deficient heterocycle integrates readily into pharmaceutical scaffolds, enabling efficient coupling in late-stage functionalization. Its bench-stable nature supports use under standard conditions without special handling requirements.

Application

3,5-Dichloropyrazine-2-carboxamide serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds through nucleophilic substitution and cross-coupling reactions. Its dichloro-substituted pyrazine core offers enhanced reactivity for late-stage functionalization, while the carboxamide group provides polarity and hydrogen-bonding capability, improving solubility and target engagement. Bench-stable and compatible with standard synthetic protocols, it facilitates rapid exploration of structure–activity relationships in kinase inhibitor and antimicrobial discovery programs.

General Information

  • CAS No. 312736-50-8
  • Cat. No. CS-W019159
  • Purity ≥97%
  • MDL No. MFCD10000837
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃Cl₂N₃O
  • Molecular Weight 192.00
  • Synonym(s) ,5-DICHLOROPYRAZINE-2-CARBOXAMIDE
  • SMILES O=C(C1=NC=C(Cl)N=C1Cl)N

Computational Chemistry Data

  • TPSA   68.87
  • LogP   0.8823
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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