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(3,5-Dichloropyrazin-2-yl)methanamine hydrochloride

  • CAS No. 2089319-25-3

  • Cat. No. CS-0068613
  • Molecule weight214.48
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(3,5-Dichloropyrazin-2-yl)methanamine hydrochloride|CS-0068613

Structure of 2089319-25-3

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General Information

  • CAS No. 2089319-25-3
  • Cat. No. CS-0068613
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆Cl₃N₃
  • Molecular Weight 214.48
  • Synonym(s) hydrochloride
  • SMILES NCC1=NC=C(Cl)N=C1Cl.[H]Cl

Description

(3,5-Dichloropyrazin-2-yl)methanamine hydrochloride delivers a highly reactive pyrazine scaffold bearing two chlorine substituents at electron-deficient positions. This bench-stable derivative integrates readily into medicinal chemistry campaigns requiring strong electron-withdrawing character and directional reactivity. The hydrochloride salt enhances solubility in polar solvents, streamlining purification and handling under standard conditions.

Application

(3,5-Dichloropyrazin-2-yl)methanamine hydrochloride serves as a versatile building block for the synthesis of pyrazine-based pharmaceutical intermediates and agrochemicals. Its dual functional groups—primary amine and electron-deficient pyrazine ring—enable straightforward coupling reactions, including Suzuki-Miyaura and Buchwald-Hartwig aminations. The hydrochloride salt enhances bench stability and simplifies purification, while the dichloro substitution pattern supports selective functionalization in late-stage diversification strategies.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   1.6639
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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