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CS-W001157 4
Total: USD 88.00

2-(Trifluoromethyl)phenylhydrazine hydrochloride

  • CAS No. 3107-34-4

  • Cat. No. CS-W014991
  • Purity≥97%
  • MDL No.MFCD00102619

*For research and further manufacturing use only, not for direct human use.

2-(Trifluoromethyl)phenylhydrazine hydrochloride|CS-W014991

Structure of 3107-34-4

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General Information

  • CAS No. 3107-34-4
  • Cat. No. CS-W014991
  • Purity ≥97%
  • MDL No. MFCD00102619
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈ClF₃N₂
  • Molecular Weight 212.60
  • Synonym(s) 2-Hydrazinobenzotrifluoride Hydrochloride
  • SMILES FC(F)(F)C1=CC=CC=C1NN.Cl

Description

2-(Trifluoromethyl)phenylhydrazine hydrochloride features a trifluoromethyl-substituted phenyl ring paired with a hydrazine functional group, delivering enhanced electrophilic reactivity and improved solubility in polar solvents. This bench-stable derivative facilitates efficient imine and azo compound synthesis under mild conditions.

Application

2-(Trifluoromethyl)phenylhydrazine hydrochloride serves as a versatile building block for heterocyclic synthesis, enabling efficient access to triazoles, pyrazoles, and other nitrogen-containing scaffolds. Its trifluoromethyl group enhances metabolic stability and lipophilicity, making it valuable in medicinal chemistry campaigns. The hydrochloride salt ensures improved bench stability and ease of handling, while maintaining high reactivity in standard coupling and cyclization protocols.

Synthesis

  • Route1
    • null|null
      115171-06-7
    • ~76%
    • In-stock
      2-(Trifluoromethyl)phenylhydrazine hydrochloride|CS-W014991
      3107-34-4

    References

    • Tetrahedron Letters, , vol. 28, # 42 p. 4933 - 4934
  • Route2
    • null|null
      395-47-1
    • ~%
    • In-stock
      2-(Trifluoromethyl)phenylhydrazine hydrochloride|CS-W014991
      3107-34-4

    References

    • Tetrahedron Letters, , vol. 28, # 42 p. 4933 - 4934

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.05
  • LogP   2.4128
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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