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CS-W001157 4
Total: USD 88.00

Trimethylsulfonium bromide

  • CAS No. 3084-53-5

  • Cat. No. CS-0128440
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Trimethylsulfonium bromide|CS-0128440

Structure of 3084-53-5

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General Information

  • CAS No. 3084-53-5
  • Cat. No. CS-0128440
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₉BrS
  • Molecular Weight 157.07
  • Synonym(s) Trimethylsulfoniumbromide; Trimethylsulfonium bromide
  • SMILES C[S+](C)C.[Br-]

Description

Trimethylsulfonium bromide serves as a potent methylating agent in organic synthesis, delivering methyl groups under mild conditions. This bench-stable reagent features a positively charged sulfonium center flanked by three methyl groups, enabling efficient methylation of nucleophiles without requiring strong bases or elevated temperatures. Its high reactivity and ease of handling make it well-suited for use in pharmaceutical intermediates, agrochemicals, and synthetic methodology development.

Application

Trimethylsulfonium bromide serves as a reliable methylating agent in organic synthesis, enabling efficient methylation of enolates and heteroatoms under mild conditions. Its bench-stable solid form facilitates handling and storage, while its compatibility with diverse functional groups supports broad utility in complex molecule construction. Widely employed in the synthesis of natural products and pharmaceutical intermediates, it functions as a key reagent for C-methylation and sulfonium ion-mediated transformations.

Synthesis

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      Trimethylsulfonium bromide|CS-0128440
      3084-53-5

    References

    • Journal of the American Chemical Society, , vol. 86, p. 1212 - 1217
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      Trimethylsulfonium bromide|CS-0128440
      3084-53-5

    References

    • Journal of Organic Chemistry, , vol. 2, p. 267,274
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      74-83-9
    • Bis(methylthio)methane, ≥99%|CS-1268336
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    • In-stock
      Trimethylsulfonium bromide|CS-0128440
      3084-53-5

    References

    • Chemische Berichte, , vol. 82, p. 433,438

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   -2.5019
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

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