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CS-W001157 4
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1-(2-Fluorophenyl)cyclopropane-1-carboxylic acid

  • CAS No. 306298-00-0

  • Cat. No. CS-W017213
  • Molecule weight180.18
  • Purity≥98%
  • MDL No.MFCD07186439

*For research and further manufacturing use only, not for direct human use.

1-(2-Fluorophenyl)cyclopropane-1-carboxylic acid|CS-W017213

Structure of 306298-00-0

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General Information

  • CAS No. 306298-00-0
  • Cat. No. CS-W017213
  • Purity ≥98%
  • MDL No. MFCD07186439
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉FO₂
  • Molecular Weight 180.18
  • Synonym(s) 1-Carboxy-1-(2-fluorophenyl)cyclopropane
  • SMILES O=C(C1(C2=CC=CC=C2F)CC1)O

Description

This cyclopropane carboxylic acid features a fluorinated phenyl ring that enhances electron-withdrawing character and metabolic stability. The rigid bicyclic framework imparts conformational restraint, ideal for probing bioactive ligand-receptor interactions in medicinal chemistry applications.

Application

1-(2-Fluorophenyl)cyclopropane-1-carboxylic acid serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of bioactive molecules through standard functional group manipulations. Its cyclopropane core imparts conformational rigidity and metabolic stability, while the ortho-fluorophenyl group enhances lipophilicity and modulates electronic properties. The carboxylic acid functionality facilitates direct derivatization or salt formation, supporting purification and formulation in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.9419
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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