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CS-W001157 4
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5-Iodo-4-methyl-1,3-thiazol-2-amine

  • CAS No. 3034-58-0

  • Cat. No. CS-0160717
  • Molecule weight240.07
  • Purity≥95%
  • MDL No.MFCD29762858

*For research and further manufacturing use only, not for direct human use.

5-Iodo-4-methyl-1,3-thiazol-2-amine|CS-0160717

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General Information

  • CAS No. 3034-58-0
  • Cat. No. CS-0160717
  • Purity ≥95%
  • MDL No. MFCD29762858
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅IN₂S
  • Molecular Weight 240.07
  • Synonym(s) 5-Iodo-4-methyl-thiazol-2-ylamine
  • SMILES NC1=NC(C)=C(I)S1

Description

5-Iodo-4-methyl-1,3-thiazol-2-amine features a reactive iodine atom at the 5-position paired with a methyl group at C4, enabling efficient cross-coupling and functionalization. The thiazole core provides enhanced stability and electron-deficient character, supporting its use in medicinal chemistry and heterocyclic synthesis. This bench-stable compound integrates readily into complex molecular architectures.

Application

5-Iodo-4-methyl-1,3-thiazol-2-amine serves as a versatile building block for constructing bioactive heterocycles, enabling palladium-catalyzed cross-coupling reactions with broad functional group tolerance. The iodine substituent facilitates efficient C–C and C–N bond formation, while the thiazole scaffold provides metabolic stability and favorable electronic properties. Bench-stable and readily purified, it functions effectively in medicinal chemistry campaigns requiring rapid diversification of thiazole-based scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.63832
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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