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CS-W001157 4
Total: USD 88.00

N-Acetyl-R-leucine

  • CAS No. 19764-30-8

  • Cat. No. CS-W020713
  • Purity≥97%
  • MDL No.MFCD00066069

*For research and further manufacturing use only, not for direct human use.

N-Acetyl-R-leucine|CS-W020713

Structure of 19764-30-8

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General Information

  • CAS No. 19764-30-8
  • Cat. No. CS-W020713
  • Purity ≥97%
  • MDL No. MFCD00066069
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₅NO₃
  • Molecular Weight 173.21
  • Synonym(s) N-Acetyl-D-leucine
  • SMILES CC(C)C[C@H](C(O)=O)NC(C)=O

Description

Hexanoic anhydride has been used in:green synthesis of esters of acyclovir (acyclovir prodrugs)preparation of hexanoyl-modified chitosan nanoparticles and chitosan-based polymeric surfactants via N-acylation of chitosans

Application

N-Acetyl-R-leucine serves as a stable, bench-ready chiral building block for peptide synthesis and medicinal chemistry applications. Its acetylated amine enhances solubility and reduces side reactions during coupling steps, while the R-configured leucine backbone provides reliable stereochemical control in bioactive molecule construction. Functions effectively in standard condensation protocols and facilitates purification due to improved polarity over the parent amino acid.

Synthesis

  • Route1
    • In-stock
      D-Leucine|CS-D1369
      328-38-1
    • null|null
      108-24-7
    • ~87%
    • In-stock
      N-Acetyl-R-leucine|CS-W020713
      19764-30-8

    References

    • Li, Xun; Branum, Shawn; Russell, Ronald K.; Jiang, Weiqin; Sui, Zhihua Organic Process Research and Development, 2005 , vol. 9, # 5 p. 640 - 645
  • Route2
    • null|null
      909122-82-3
    • ~77%
    • In-stock
      N-Acetyl-R-leucine|CS-W020713
      19764-30-8

    References

    • JANSSEN PHARMACEUTICA, N.V. Patent: WO2006/93719 A1, 2006 ; Location in patent: Page/Page column 15; 33; 34 ;
  • Route3
    • null|null
      84591-31-1
    • ~%
    • In-stock
      N-Acetyl-R-leucine|CS-W020713
      19764-30-8

    References

    • WO2006/93719 A1, ; Page/Page column 15; 31; 32 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   66.4
  • LogP   0.6218
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   4

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