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CS-W001157 4
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5-Bromothiazole

  • CAS No. 3034-55-7

  • Cat. No. CS-D1067
  • Purity≥98%
  • MDL No.MFCD07787394

*For research and further manufacturing use only, not for direct human use.

5-Bromothiazole|CS-D1067

Structure of 3034-55-7

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General Information

  • CAS No. 3034-55-7
  • Cat. No. CS-D1067
  • Purity ≥98%
  • MDL No. MFCD07787394
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₂BrNS
  • Molecular Weight 164.02
  • Synonym(s) 5-bromo-Thiazole
  • SMILES BrC1=CN=CS1

Description

5-Bromothiazole is a bench-stable, moisture-tolerant heterocycle featuring a bromine substituent at the 5-position of the thiazole ring. This strategic halogenation enables direct functionalization in cross-coupling reactions, facilitating efficient integration into complex molecular architectures. The electron-deficient nature of the ring enhances reactivity in palladium-catalyzed transformations, making it a valuable scaffold for medicinal chemistry and materials synthesis.

Synthesis

  • Route1

    References

    • Bulletin de la Societe Chimique de France, , p. 2075 - 2078
  • Route2

    References

    • Gol'dfarb, Ya. L.; Gromova, G. P.; Belen'kii, L. I. Chemistry of Heterocyclic Compounds (New York, NY, United States), 1986 , vol. 22, # 6 p. 663 - 666 Khimiya Geterotsiklicheskikh Soedinenii, 1986 , vol. 22, # 6 p. 837 - 840
  • Route3
    • In-stock
      2-(Trimethylsilyl)thiazole|CS-W010908
      79265-30-8
    • ~%
    • In-stock
      5-Bromothiazole|CS-D1067
      3034-55-7
    • 5-Bromo-2-iodothiazole|CS-0040254
      108306-64-5

    References

    • Synthesis, , # 9 p. 757 - 760

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H227-H302-H315-H317-H318-H335
Precautionary Statements : P210-P261-P264-P270-P271-P272-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P403-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.9056
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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