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CS-W001157 4
Total: USD 88.00

8-Methoxy-2-methylquinoline

  • CAS No. 3033-80-5

  • Cat. No. CS-0102192
  • Purity≥97%
  • MDL No.MFCD00034436

*For research and further manufacturing use only, not for direct human use.

8-Methoxy-2-methylquinoline|CS-0102192

Structure of 3033-80-5

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General Information

  • CAS No. 3033-80-5
  • Cat. No. CS-0102192
  • Purity ≥97%
  • MDL No. MFCD00034436
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₁NO
  • Molecular Weight 173.21
  • Synonym(s) 8-Methoxyquinaldine
  • SMILES CC1=NC2=C(OC)C=CC=C2C=C1

Description

8-Methoxy-2-methylquinoline is a heterocyclic compound featuring a quinoline core with methoxy and methyl substituents at the 8- and 2-positions, respectively. This electron-rich scaffold exhibits enhanced solubility and stability under standard conditions, enabling efficient integration into ligand design, catalytic systems, and fluorescent probe development.

Application

8-Methoxy-2-methylquinoline serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to quinoline-based scaffolds. Its methoxy and methyl substituents provide orthogonal reactivity for late-stage functionalization, while its bench-stable nature facilitates handling in multi-step syntheses. The compound functions effectively in Pd-catalyzed coupling reactions and serves as a core motif in the development of kinase inhibitors and antimalarial agents.

Synthesis

  • Route1
    • In-stock
      2-Methylquinolin-8-ol|CS-W004053
      826-81-3
    • null|null
      74-88-4
    • ~97%
    • In-stock
      8-Methoxy-2-methylquinoline|CS-0102192
      3033-80-5

    References

    • Malecki, Grzegorz; Nycz, Jacek E.; Ryrych, Ewa; Ponikiewski, Lukasz; Nowak, Maria; Kusz, Joachim; Pikies, Jerzy Journal of Molecular Structure, 2010 , vol. 969, # 1-3 p. 130 - 138
  • Route2
    • null|null
      90-04-0
    • null|null
      123-73-9
    • ~97%
    • In-stock
      8-Methoxy-2-methylquinoline|CS-0102192
      3033-80-5

    References

    • Chaskar, Atul; Padalkar, Vikas; Phatangare, Kiran; Langi, Bhushan; Shah, Chetan Synthetic Communications, 2010 , vol. 40, # 15 p. 2336 - 2340
  • Route3
    • null|null
      191484-58-9
    • ~4%
    • In-stock
      8-Methoxy-2-methylquinoline|CS-0102192
      3033-80-5
    • In-stock
      6-Methoxy-2-methylquinoline|CS-W005964
      1078-28-0

    References

    • Synthesis, , # 15 p. 2415 - 2426

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P305+P351+P338-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   2.55182
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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