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CS-W001157 4
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2-[Difluoro-(3,4,5-trifluorophenoxy)Methyl]-5-(4-ethylphenyl)-1,3-difluoro-benzene

  • CAS No. 303186-19-8

  • Cat. No. CS-0059885
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-[Difluoro-(3,4,5-trifluorophenoxy)Methyl]-5-(4-ethylphenyl)-1,3-difluoro-benzene|CS-0059885

Structure of 303186-19-8

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General Information

  • CAS No. 303186-19-8
  • Cat. No. CS-0059885
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₁H₁₃F₇O
  • Molecular Weight 414.32
  • Synonym(s) 4-(Difluoro(3,4,5-trifluorophenoxy)methyl)-4'-ethyl-3,5-difluoro-1,1'-biphenyl
  • SMILES C=1(C=C(C(=C(C1)F)C(OC=2C=C(C(=C(C2)F)F)F)(F)F)F)C=3C=CC(=CC3)CC

Description

This difluorinated benzene derivative features a trifluorophenoxy-linked methyl group and an ethylphenyl substituent, delivering enhanced lipophilicity and metabolic stability. Designed for advanced medicinal chemistry applications, it integrates readily into complex scaffolds under standard conditions.

Application

2-[Difluoro-(3,4,5-trifluorophenoxy)methyl]-5-(4-ethylphenyl)-1,3-difluoro-benzene serves as a versatile fluorinated aromatic building block for medicinal chemistry and materials science. Its trifluorophenyl ether moiety enables enhanced metabolic stability and lipophilicity, while the difluoromethyl and ethylphenyl groups provide orthogonal functional handles for downstream derivatization. The compound exhibits good bench stability and facilitates efficient coupling reactions in standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   6.7398
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   5

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