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CS-W001157 4
Total: USD 88.00

2,4-Dibromo-6-methylaniline

  • CAS No. 30273-41-7

  • Cat. No. CS-0036156
  • Purity≥98%
  • MDL No.MFCD00735681

*For research and further manufacturing use only, not for direct human use.

2,4-Dibromo-6-methylaniline|CS-0036156

Structure of 30273-41-7

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General Information

  • CAS No. 30273-41-7
  • Cat. No. CS-0036156
  • Purity ≥98%
  • MDL No. MFCD00735681
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇Br₂N
  • Molecular Weight 264.95
  • Synonym(s) None
  • SMILES CC1=CC(=CC(=C1N)Br)Br

Description

2,4-Dibromo-6-methylaniline features a methylaniline core with bromine substituents at the 2 and 4 positions, delivering enhanced electrophilic reactivity and steric control. This bench-stable derivative serves as a key building block in the synthesis of functionalized aromatic scaffolds, particularly in pharmaceutical intermediates and advanced materials where halogenation patterns dictate downstream coupling efficiency.

Application

2,4-Dibromo-6-methylaniline serves as a versatile building block for the synthesis of functionalized heterocycles and pharmaceutical intermediates. Its ortho-bromine substituents enable palladium-catalyzed cross-coupling reactions, while the aniline nitrogen and methyl group offer sites for further derivatization. The compound exhibits good bench stability and facilitates efficient purification, making it well-suited for iterative synthetic workflows in medicinal chemistry and process development.

Synthesis

  • Route1

    References

    • Hajipour; Imanieh; Pourmousavi Synthetic Communications, 2004 , vol. 34, # 24 p. 4597 - 4604
  • Route2
    • null|null
      95-53-4
    • ~95%
    • In-stock
      2,4-Dibromo-6-methylaniline|CS-0036156
      30273-41-7

    References

    • Kajigaeshi, Shoji; Kakinami, Takaaki; Inoue, Kazuhisa; Kondo, Manabu; Nakamura, Hiroko; et al. Bulletin of the Chemical Society of Japan, 1988 , vol. 61, # 2 p. 597 - 599
  • Route3
    • null|null
      861603-65-8
    • ~%
    • In-stock
      2,4-Dibromo-6-methylaniline|CS-0036156
      30273-41-7

    References

    • Journal of the American Chemical Society, , vol. 36, p. 321

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   3.10222
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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