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Structure of 301856-25-7
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5,7-Difluoro-1H-indole delivers a highly electron-deficient indole scaffold with enhanced metabolic stability. The ortho-fluorination pattern increases binding affinity in target-directed synthesis and improves solubility in polar aprotic solvents. This bench-stable heterocycle integrates efficiently into medicinal chemistry libraries and serves as a key building block for kinase inhibitors and CNS-targeted pharmacophores.
5,7-Difluoro-1H-indole serves as a valuable building block in medicinal chemistry, enabling direct incorporation of fluorinated aryl motifs into biologically active scaffolds. Its electron-deficient indole core facilitates electrophilic substitution and transition-metal-catalyzed coupling reactions, while the fluorine substituents enhance metabolic stability and modulate electronic properties. The compound exhibits bench stability and compatibility with common purification methods, making it well-suited for iterative synthesis and library generation in drug discovery workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: