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3-Bromo-6-(difluoromethyl)-2-ethoxypyridine

  • CAS No. 3008582-86-0

  • Cat. No. CS-0619902
  • Molecule weight252.06
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Bromo-6-(difluoromethyl)-2-ethoxypyridine|CS-0619902

Structure of 3008582-86-0

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General Information

  • CAS No. 3008582-86-0
  • Cat. No. CS-0619902
  • Purity ≥96%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈BrF₂NO
  • Molecular Weight 252.06
  • Synonym(s) None
  • SMILES BrC1=CC=C(N=C1OCC)C(F)F

Description

3-Bromo-6-(difluoromethyl)-2-ethoxypyridine features a strategically positioned difluoromethyl group that enhances metabolic stability and modulates electronic properties. The bromine at C3 enables direct coupling in cross-coupling reactions, while the ethoxy substituent improves solubility and processability. This pyridine derivative serves as a key building block for bioactive molecules in medicinal chemistry and agrochemical development under standard conditions.

Application

3-Bromo-6-(difluoromethyl)-2-ethoxypyridine serves as a versatile building block in medicinal chemistry, enabling late-stage functionalization via palladium-catalyzed cross-coupling reactions. The bromo group facilitates efficient C–C and C–heteroatom bond formation, while the difluoromethyl and ethoxy substituents provide enhanced metabolic stability and tunable lipophilicity. This compound exhibits excellent bench stability and compatibility with standard synthetic workflows, making it well-suited for the construction of complex heterocyclic scaffolds in API development.

Safety Information

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   3.1804
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   3

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