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CS-W001157 4
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(3aS,8aS)-2,2-Dimethyl-4,4,6,8,8-pentaphenyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine

  • CAS No. 300811-56-7

  • Cat. No. CS-0198510
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(3aS,8aS)-2,2-Dimethyl-4,4,6,8,8-pentaphenyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine|CS-0198510

Structure of 300811-56-7

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General Information

  • CAS No. 300811-56-7
  • Cat. No. CS-0198510
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₇H₃₃O₄P
  • Molecular Weight 572.63
  • Synonym(s) 1,3-Dioxolo[4,5-e][1,3,2]dioxaphosphepin, tetrahydro-2,2-dimethyl-4,4,6,8,8-pentaphenyl-, (3aS,8aS)-
  • SMILES CC1(C)O[C@H](C(C2=CC=CC=C2)(OP(C3=CC=CC=C3)O4)C5=CC=CC=C5)[C@@H](C4(C6=CC=CC=C6)C7=CC=CC=C7)O1

Description

This tetrahydro[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine features a rigid, electron-deficient phosphorus center flanked by five phenyl groups and two methyl substituents, delivering exceptional stability and controlled reactivity. Designed for precision applications in catalytic synthesis and materials chemistry, it integrates readily into complex molecular architectures under standard conditions.

Application

(3aS,8aS)-2,2-Dimethyl-4,4,6,8,8-pentaphenyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine serves as a sterically encumbered, bench-stable phosphorus-containing building block for the synthesis of chiral phosphine ligands and catalysts. Its rigid fused heterocyclic framework enables high enantioselectivity in transition-metal-catalyzed cross-coupling reactions, while the phenyl and methyl substituents provide excellent functional group tolerance and ease of purification.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   36.92
  • LogP   8.0783
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   5

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