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CS-W001157 4
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2-(tert-Butoxycarbonyl)-2,3,4,5-tetrahydro-1h-pyrido[4,3-b]indole-8-carboxylicacid

  • CAS No. 300715-96-2

  • Cat. No. CS-0171765
  • Molecule weight316.35
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(tert-Butoxycarbonyl)-2,3,4,5-tetrahydro-1h-pyrido[4,3-b]indole-8-carboxylicacid|CS-0171765

Structure of 300715-96-2

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General Information

  • CAS No. 300715-96-2
  • Cat. No. CS-0171765
  • Purity ≥97%
  • MDL No. None
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₂₀N₂O₄
  • Molecular Weight 316.35
  • Synonym(s) 2-(Tert-butoxycarbonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-B]indole-8-carboxylic acid
  • SMILES CC(C)(C)OC(=O)N1CCC2=C(C1)C3=C(C=CC(=C3)C(=O)O)N2

Synthesis

  • Route1

    References

    • AstraZeneca AB Patent: WO2006/101434 A1, 2006 ; Location in patent: Page/Page column 24; 30; 31 ; WO 2006/101434 A1
  • Route2

    References

    • Ferguson, Fleur M.; Fedorov, Oleg; Chaikuad, Apirat; Philpott, Martin; Muniz, Joao R. C.; Felletar, Ildiko; Von Delft, Frank; Heightman, Tom; Knapp, Stefan; Abell, Chris; Ciulli, Alessio Journal of Medicinal Chemistry, 2013 , vol. 56, # 24 p. 10183 - 10187
  • Route3
    • 4-Hydrazinylbenzoic acid Lamivudine  Impurity|CS-0229071
      619-67-0
    • ~%
    • 2-(tert-Butoxycarbonyl)-2,3,4,5-tetrahydro-1h-pyrido[4,3-b]indole-8-carboxylicacid|CS-0171765
      300715-96-2

    References

    • Cheng, Yun-Xing; Pourashraf, Mehrnaz; Luo, Xuehong; Srivastava, Sanjay; Walpole, Christopher; Salois, Dominic; St-Onge, Stephane; Payza, Kemal; Lessard, Etienne; Yu, Xiao Hong; Tomaszewski, Miroslaw J. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1619 - 1624

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   82.63
  • LogP   3.1593
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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