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CS-W001157 4
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Morpholine-2-carboxylic acid

  • CAS No. 300582-83-6

  • Cat. No. CS-0103628
  • Molecule weight131.13
  • Purity≥96%
  • MDL No.MFCD03788074

*For research and further manufacturing use only, not for direct human use.

Morpholine-2-carboxylic acid|CS-0103628

Structure of 300582-83-6

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General Information

  • CAS No. 300582-83-6
  • Cat. No. CS-0103628
  • Purity ≥96%
  • MDL No. MFCD03788074
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉NO₃
  • Molecular Weight 131.13
  • Synonym(s) H-COP-OH HCL
  • SMILES O=C(C1CNCCO1)O

Description

Morpholine-2-carboxylic acid serves as a key scaffold in medicinal chemistry, integrating a polar morpholine ring with a carboxylic acid functionality. This combination enables robust hydrogen bonding and improved solubility in aqueous systems, enhancing its utility in drug discovery workflows. The molecule exhibits stability under standard bench conditions and facilitates efficient conjugation reactions.

Application

Morpholine-2-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and peptide-like scaffolds. Its amide functionality facilitates conjugation and derivatization under standard coupling conditions, while the morpholine ring provides favorable solubility and metabolic stability. The carboxylic acid group offers direct handle for further functionalization, enhancing its utility in library synthesis and lead optimization workflows.

Synthesis

  • Route1

    References

    • WO2011/17578 A1, ; Page/Page column 134 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   58.56
  • LogP   -0.9406
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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