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Structure of 298709-29-2
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3,5-Difluoropicolinonitrile features a pyridine ring bearing two fluorine substituents at the 3 and 5 positions and a nitrile group at the 2 position. This electron-deficient heterocycle integrates readily into synthetic sequences requiring strong acceptor character. The difluoro substitution enhances metabolic stability and modulates reactivity for use in medicinal chemistry and agrochemical development.
3,5-Difluoropicolinonitrile serves as a versatile building block in medicinal chemistry, enabling direct incorporation of fluorinated heterocyclic motifs into bioactive molecules. Its pyridine core exhibits enhanced metabolic stability and improved membrane permeability, while the nitrile group facilitates downstream transformations via hydrolysis, reduction, or nucleophilic addition. The 3,5-difluoro substitution pattern provides predictable electronic effects and orthogonality in multi-step syntheses, making it ideal for constructing advanced API scaffolds with controlled polarity and targeted reactivity.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 1760
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H318-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: