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CS-W001157 4
Total: USD 88.00

3,5-Difluoropicolinonitrile

  • CAS No. 298709-29-2

  • Cat. No. CS-W008080
  • Purity≥98%
  • MDL No.MFCD03788759
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3,5-Difluoropicolinonitrile|CS-W008080

Structure of 298709-29-2

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Description

3,5-Difluoropicolinonitrile features a pyridine ring bearing two fluorine substituents at the 3 and 5 positions and a nitrile group at the 2 position. This electron-deficient heterocycle integrates readily into synthetic sequences requiring strong acceptor character. The difluoro substitution enhances metabolic stability and modulates reactivity for use in medicinal chemistry and agrochemical development.

Application

3,5-Difluoropicolinonitrile serves as a versatile building block in medicinal chemistry, enabling direct incorporation of fluorinated heterocyclic motifs into bioactive molecules. Its pyridine core exhibits enhanced metabolic stability and improved membrane permeability, while the nitrile group facilitates downstream transformations via hydrolysis, reduction, or nucleophilic addition. The 3,5-difluoro substitution pattern provides predictable electronic effects and orthogonality in multi-step syntheses, making it ideal for constructing advanced API scaffolds with controlled polarity and targeted reactivity.

General Information

  • CAS No. 298709-29-2
  • Cat. No. CS-W008080
  • Purity ≥98%
  • MDL No. MFCD03788759
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₂F₂N₂
  • Molecular Weight 140.09
  • Synonym(s) None
  • SMILES C1=C(F)C(=NC=C1F)C#N

Computational Chemistry Data

  • TPSA   36.68
  • LogP   1.23148
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group :
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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