1H-Pyrazolo[3,4-b]pyridin-3(2H)-one

Name: 1H-Pyrazolo[3,4-b]pyridin-3(2H)-one
Brand: ChemScene
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CAS No. 2942-43-0
Cat. No. CS-0044051
Purity≥97%
MDL No.MFCD03013435

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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1H-Pyrazolo[3,4-b]pyridin-3(2H)-one|CS-0044051

Structure of 2942-43-0

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General Information

CAS No. 2942-43-0
Cat. No. CS-0044051
Purity ≥97%
MDL No. MFCD03013435
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅N₃O
Molecular Weight 135.12
Synonym(s) 1,2-dihydro-3H-pyrazolo[3,4-b]pyridin-3-one
SMILES O=C1NNC2=C1C=CC=N2

Description

1H-Pyrazolo[3,4-b]pyridin-3(2H)-one is a heterocyclic scaffold featuring a fused pyrazole-pyridine core with a lactam functionality. This electron-deficient system enables robust integration into bioactive molecules, particularly as a privileged structure in kinase inhibitors and medicinal chemistry campaigns. The compound exhibits favorable solubility and stability under standard bench conditions, facilitating efficient incorporation into synthetic workflows.

Application

1H-Pyrazolo[3,4-b]pyridin-3(2H)-one serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds through well-established functionalization at the 2- and 6-positions. Its stability under standard reaction conditions and compatibility with common coupling protocols facilitate downstream derivatization. The molecule functions as a key core structure in kinase inhibitor development and other target-oriented syntheses, offering predictable reactivity and ease of purification.

Synthesis

Route1
- 1452-94-4
- ~95%
- In-stock
  
  2942-43-0
References
- Aventis Pharma Deutschland GmbH Patent: US2005/197348 A1, 2005 ; Location in patent: Page/Page column 10 ;
Route2
- In-stock
  
  40134-18-7
- ~%
- In-stock
  
  2942-43-0
References
- ABBOTT LABORATORIES Patent: WO2003/76408 A2, 2003 ; Location in patent: Page/Page column 41 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 61.54
LogP 0.2512
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Key Words

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1H-Pyrazolo[3,4-b]pyridin-3(2H)-one

CAS No. 2942-43-0

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