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CS-W001157 4
Total: USD 88.00

1,2-Difluoro-4-methylbenzene

  • CAS No. 2927-34-6

  • Cat. No. CS-W013471
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1,2-Difluoro-4-methylbenzene|CS-W013471

Structure of 2927-34-6

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General Information

  • CAS No. 2927-34-6
  • Cat. No. CS-W013471
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆F₂
  • Molecular Weight 128.12
  • Synonym(s) Benzene, 1,2-difluoro-4-methyl-
  • SMILES CC1=CC=C(F)C(F)=C1

Description

NH2-PEG1-Val-Cit-PAB-OH is a cleavable ADC linker intermediate featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

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Computational Chemistry Data

  • TPSA   0
  • LogP   2.27322
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

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