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CS-W001157 4
Total: USD 88.00

1-Benzylpiperidine

  • CAS No. 2905-56-8

  • Cat. No. CS-0156287
  • Purity≥98%
  • MDL No.MFCD00224901

*For research and further manufacturing use only, not for direct human use.

1-Benzylpiperidine|CS-0156287

Structure of 2905-56-8

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General Information

  • CAS No. 2905-56-8
  • Cat. No. CS-0156287
  • Purity ≥98%
  • MDL No. MFCD00224901
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₇N
  • Molecular Weight 175.27
  • Synonym(s) N-benzylpiperidine
  • SMILES C1=CC=C(C=C1)CN2CCCCC2

Description

1-Benzylpiperidine is a versatile nitrogen-containing heterocycle featuring a benzyl group attached to the piperidine ring. This configuration imparts enhanced lipophilicity and metabolic stability, making it valuable in medicinal chemistry for optimizing pharmacokinetic properties. The molecule integrates readily into bioactive scaffolds, particularly in CNS-targeted drug discovery, where its basic amine functionality enables salt formation and solubility tuning under standard conditions.

Application

1-Benzylpiperidine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocyclic scaffolds. Its benzylic nitrogen facilitates straightforward functionalization and acts as a key pharmacophore in CNS-targeted compounds. The molecule exhibits excellent bench stability, compatibility with standard coupling reactions, and ease of purification, making it well-suited for high-throughput synthesis and process development.

Synthesis

  • Route1
    • null|null
      110-89-4
    • null|null
      100-39-0
    • ~95%
    • In-stock
      1-Benzylpiperidine|CS-0156287
      2905-56-8

    References

    • Sperotto, Elena; van Klink, Gerard P.M.; de Vries, Johannes G.; van Koten, Gerard Tetrahedron, 2010 , vol. 66, # 19 p. 3478 - 3484
  • Route2

    References

    • Zhou, Shaolin; Junge, Kathrin; Addis, Daniele; Das, Shoubhik; Beller, Matthias Angewandte Chemie - International Edition, 2009 , vol. 48, # 50 p. 9507 - 9510
  • Route3

    References

    • Kano, Shinzo; Tanaka, Yasuyuki; Sugino, Eiichi; Hibino, Sstoshi Synthesis, 1980 , # 9 p. 695 - 697

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   3.24
  • LogP   2.6725
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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