Lot numbers can be found on the outside label of a product:
(2-Aminophenyl)(2-chlorophenyl)methanone
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CAS No. 2894-45-3
- Cat. No. CS-0162342
- Purity≥97%
- MDL No.MFCD09835337
*For research and further manufacturing use only, not for direct human use.
Structure of 2894-45-3
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General Information
- CAS No. 2894-45-3
- Cat. No. CS-0162342
- Purity ≥97%
- MDL No. MFCD09835337
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₃H₁₀ClNO
- Molecular Weight 231.68
- Synonym(s) 2-Amino-2'-chlorobenzophenone
- SMILES O=C(C1=CC=CC=C1N)C2=CC=CC=C2Cl
Description
This aryl ketone features a strategically positioned amine and chlorophenyl group, enabling direct incorporation into bioactive scaffolds. The ortho-aminobenzoyl motif facilitates metal coordination and hydrogen bonding in catalytic systems, while the chlorophenyl moiety enhances lipophilicity and electron-withdrawing character. Designed for synthetic versatility, it integrates readily into pharmaceutical intermediates and functional materials under standard conditions.
Application
(2-Aminophenyl)(2-chlorophenyl)methanone serves as a versatile building block in medicinal chemistry, enabling the construction of fused heterocyclic scaffolds through facile cyclization reactions. Its ortho-amino and chlorophenyl groups facilitate directed metalation and subsequent coupling processes, offering robust access to bioactive core structures. The compound exhibits good bench stability and compatibility with standard purification methods, making it well-suited for iterative synthetic workflows in API development.
Synthesis
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Route1
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622372-96-7 - ~82%
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In-stock
2894-45-3
References
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ELI LILLY AND COMPANY Patent: WO2003/91226 A1, 2003 ; Location in patent: Page/Page column 44 ; WO 03/091226 A1
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Route2
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2894-44-2
- ~%
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In-stock
2894-45-3
References
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Sternbach,L.H. et al. Journal of Medicinal Chemistry, 1963 , vol. 6, p. 261 - 265
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Route3
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1444-72-0
- ~%
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In-stock
2894-45-3
References
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Sternbach,L.H. et al. Journal of Medicinal Chemistry, 1963 , vol. 6, p. 261 - 265
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 43.09
- LogP 3.1532
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 2
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Key Words
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