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CS-W001157 4
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(2-(Difluoromethoxy)phenyl)methanamine

  • CAS No. 243863-36-7

  • Cat. No. CS-0052680
  • Purity≥98%
  • MDL No.MFCD00236229

*For research and further manufacturing use only, not for direct human use.

(2-(Difluoromethoxy)phenyl)methanamine|CS-0052680

Structure of 243863-36-7

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General Information

  • CAS No. 243863-36-7
  • Cat. No. CS-0052680
  • Purity ≥98%
  • MDL No. MFCD00236229
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉F₂NO
  • Molecular Weight None
  • Synonym(s) 2-(Difluoromethoxy)benzylamine
  • SMILES NCC1=C(OC(F)F)C=CC=C1

Description

This difluoromethoxy-substituted aniline derivative features a para-difluoromethoxy group that enhances metabolic stability and lipophilicity, enabling efficient integration into bioactive scaffolds. The primary amine facilitates conjugation and derivatization under standard coupling conditions.

Application

(2-(Difluoromethoxy)phenyl)methanamine serves as a valuable building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its difluoromethoxy group imparts enhanced metabolic stability and modulated lipophilicity, while the primary amine facilitates straightforward derivatization via acylation, alkylation, or coupling reactions. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for scalable synthesis and structure-activity studies.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314-H318
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P405-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.7467
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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