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Structure of 28899-75-4
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7-Chloro-1H-indole-2-carboxylic acid is a bench-stable, electron-deficient heterocyclic building block featuring a chlorine substituent at the 7-position and a carboxylic acid group at C2. This combination enables direct incorporation into pharmaceutical intermediates, enabling efficient access to bioactive indole derivatives through coupling and cyclization reactions.
7-Chloro-1H-indole-2-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into biologically active indole scaffolds. Its carboxylic acid functionality facilitates amide bond formation, esterification, and coupling reactions with amines or alcohols under standard conditions. The 7-chloro substituent enhances electrophilic reactivity and provides a handle for further functionalization via cross-coupling or nucleophilic substitution. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step syntheses of heterocyclic compounds and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: