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CS-W001157 4
Total: USD 88.00

4,5,6,7-Tetrahydrothieno[2,3-c]pyridine hydrochloride

  • CAS No. 28783-38-2

  • Cat. No. CS-W006263
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4,5,6,7-Tetrahydrothieno[2,3-c]pyridine hydrochloride|CS-W006263

Structure of 28783-38-2

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General Information

  • CAS No. 28783-38-2
  • Cat. No. CS-W006263
  • Purity ≥96%
  • MDL No. None
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀ClNS
  • Molecular Weight 175.68
  • Synonym(s) None
  • SMILES C1(C=CS2)=C2CNCC1.Cl

Description

This tetrahydrothienopyridine hydrochloride features a fused heterocyclic core with enhanced solubility and stability under standard conditions. The protonated nitrogen facilitates salt formation, improving handling and crystallization properties. This scaffold integrates readily into medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds.

Application

4,5,6,7-Tetrahydrothieno[2,3-c]pyridine hydrochloride serves as a versatile heterocyclic building block in medicinal chemistry, offering a rigid, electron-rich scaffold with enhanced metabolic stability. The hydrochloride salt ensures excellent solubility and bench stability, facilitating straightforward handling and purification. It functions as a key intermediate in the synthesis of bioactive molecules, particularly those requiring fused thienopyridine motifs, enabling efficient functionalization at multiple sites through standard coupling and electrophilic substitution protocols.

Synthesis

  • Route1

    References

    • Takeda Chemical Industries, Ltd. Patent: US5998433 A1, 1999 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.8156
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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