Lot numbers can be found on the outside label of a product:
3-Chloro-1H-indole-2-carboxylic acid
-
CAS No. 28737-32-8
- Cat. No. CS-0044988
- Purity≥97%
- MDL No.MFCD11007738
*For research and further manufacturing use only, not for direct human use.
Structure of 28737-32-8
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 28737-32-8
- Cat. No. CS-0044988
- Purity ≥97%
- MDL No. MFCD11007738
- Storage -20°C, sealed storage, away from moisture
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₆ClNO₂
- Molecular Weight 195.60
- Synonym(s) 3-chloro-2-indole acid
- SMILES O=C(C(N1)=C(Cl)C2=C1C=CC=C2)O
Description
3-Chloro-1H-indole-2-carboxylic acid features a chlorinated indole core with a carboxylic acid group at the C2 position, enabling direct conjugation in heterocyclic synthesis. The electron-withdrawing chlorine enhances reactivity in electrophilic substitution and facilitates coupling reactions under standard conditions. This bench-stable derivative serves as a key scaffold for bioactive molecule development.
Application
3-Chloro-1H-indole-2-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into indole-based scaffolds through standard coupling reactions. Its carboxylic acid group facilitates amide and ester formation under common conditions, while the 3-chloro substituent offers a handle for subsequent cross-coupling or nucleophilic substitution. The compound exhibits good bench stability and is compatible with diverse functional groups, supporting efficient synthesis of complex heterocyclic systems and API intermediates.
Synthesis
-
Route1
-
In-stock
38343-91-8 - ~97%
-
In-stock
28737-32-8
References
-
Seifert, Katrin; Buettner, Anita; Rigol, Stephan; Eilert, Nicole; Giannis, Athanassios; Wandel, Elke Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 21 p. 6465 - 6481,17
-
-
Route2
-
In-stock
1477-50-5 - ~88%
-
In-stock
28737-32-8
References
-
Richter Gedeon Nyrt.; Beke, Gyula; Bényei, Gyula Attila; Borza, István; Bozó, Éva; Farkas, Sándor; Hornok, Katalin; Papp, Andrea; Vágó, István; Vastag, Mónika Patent: US2013/217702 A1, 2013 ; Location in patent: Paragraph 0114 ;
-
-
Route3
-
In-stock
3770-50-1 - ~%
-
In-stock
28737-32-8
References
-
Seifert, Katrin; Buettner, Anita; Rigol, Stephan; Eilert, Nicole; Giannis, Athanassios; Wandel, Elke Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 21 p. 6465 - 6481,17
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H319-H335
|
|
|
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 53.09
- LogP 2.5195
- H_Acceptors 1
- H_Donors 2
- Rotatable_Bonds 1
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 3-Chloro-1H-indole-2-carboxylic acid sigma3-Chloro-1H-indole-2-carboxylic acid manufacturer3-Chloro-1H-indole-2-carboxylic acid price3-Chloro-1H-indole-2-carboxylic acid structure3-Chloro-1H-indole-2-carboxylic acid SDSbuy 3-Chloro-1H-indole-2-carboxylic acid3-Chloro-1H-indole-2-carboxylic acid supplier3-Chloro-1H-indole-2-carboxylic acid uses3-Chloro-1H-indole-2-carboxylic acid molecular weightprice of 3-Chloro-1H-indole-2-carboxylic acid3-Chloro-1H-indole-2-carboxylic acid chemical name formula of 3-Chloro-1H-indole-2-carboxylic acid