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CS-W001157 4
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1H-Pyrrolo[3,2-c]pyridine-2-carboxylic acid

  • CAS No. 800401-65-4

  • Cat. No. CS-D0022
  • Purity≥98%
  • MDL No.MFCD09743299

*For research and further manufacturing use only, not for direct human use.

1H-Pyrrolo[3,2-c]pyridine-2-carboxylic acid|CS-D0022

Structure of 800401-65-4

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General Information

  • CAS No. 800401-65-4
  • Cat. No. CS-D0022
  • Purity ≥98%
  • MDL No. MFCD09743299
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆N₂O₂
  • Molecular Weight 162.15
  • Synonym(s) 5-AZAINDOLE-2-CARBOXYLIC ACID
  • SMILES O=C(C(N1)=CC2=C1C=CN=C2)O

Description

1H-Pyrrolo[3,2-c]pyridine-2-carboxylic acid features a fused heterocyclic core with a carboxylic acid group at the 2-position, enabling direct incorporation into bioactive scaffolds. The electron-deficient pyridine ring enhances reactivity in coupling reactions, while the acidic proton facilitates salt formation and solubility modulation. This structure serves as a key building block for pharmaceutical intermediates and functional materials.

Application

1H-Pyrrolo[3,2-c]pyridine-2-carboxylic acid serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to structurally diverse scaffolds. Its carboxylic acid functionality facilitates direct amidation, esterification, and coupling reactions, while the fused pyrrolopyridine core exhibits favorable stability and compatibility with common reaction conditions. This compound functions as a key intermediate in the synthesis of kinase inhibitors and other bioactive molecules, offering robust reactivity and straightforward purification.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   65.98
  • LogP   1.2611
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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