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CS-W001157 4
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Ethyl4-hydroxy-2-oxo-1,2-dihydropyrimidine-5-carboxylate

  • CAS No. 28485-17-8

  • Cat. No. CS-0042918
  • Purity≥95%
  • MDL No.MFCD00057337
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Ethyl4-hydroxy-2-oxo-1,2-dihydropyrimidine-5-carboxylate|CS-0042918

Structure of 28485-17-8

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Description

Ethyl 4-hydroxy-2-oxo-1,2-dihydropyrimidine-5-carboxylate serves as a key heterocyclic scaffold in medicinal chemistry, featuring a hydroxyl group at C4 and a carbonyl at C2 that enable diverse functionalization. This bench-stable intermediate integrates readily into synthetic sequences for pyrimidine-based bioactive compounds.

Application

Ethyl 4-hydroxy-2-oxo-1,2-dihydropyrimidine-5-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to pyrimidine-based scaffolds. The molecule features orthogonal functional groups—carboxylate ester and enolizable C4 hydroxyl—that facilitate sequential transformations. It participates reliably in nucleophilic additions, condensations, and cyclizations under mild conditions, with demonstrated stability for bench storage and straightforward purification. Widely used in medicinal chemistry and agrochemical research, it functions as a key intermediate in the construction of bioactive pyrimidines.

General Information

  • CAS No. 28485-17-8
  • Cat. No. CS-0042918
  • Purity ≥95%
  • MDL No. MFCD00057337
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈N₂O₄
  • Molecular Weight 184.15
  • Synonym(s) Ethyluracil-5-carboxylate
  • SMILES O=C(C1=CNC(N=C1O)=O)OCC

Computational Chemistry Data

  • TPSA   92.28
  • LogP   -0.3478
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   2

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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