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CS-W001157 4
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4-(4-Aminophenoxy)-N-methylpicolinamide Sorafenib Impurity

  • CAS No. 284462-37-9

  • Cat. No. CS-0167173
  • Purity≥98%
  • MDL No.MFCD08692047

*For research and further manufacturing use only, not for direct human use.

4-(4-Aminophenoxy)-N-methylpicolinamide Sorafenib Impurity|CS-0167173

Structure of 284462-37-9

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General Information

  • CAS No. 284462-37-9
  • Cat. No. CS-0167173
  • Purity ≥98%
  • MDL No. MFCD08692047
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₃N₃O₂
  • Molecular Weight 243.27
  • Synonym(s) None
  • SMILES O=C(C1=NC=CC(OC2=CC=C(N)C=C2)=C1)NC

Synthesis

  • Route1

    References

    • WO2012/112570 A1, ; Page/Page column 57 ; WO 2012/112570 A1
  • Route2
    • null|null
      123-30-8
    • 4-Chloro-N-methyl-2-pyridinecarboxamide Sorafenib Impurity|CS-0181543
      220000-87-3
    • ~99%
    • 4-(4-Aminophenoxy)-N-methylpicolinamide Sorafenib Impurity|CS-0167173
      284462-37-9

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 8 p. 2220 - 2223
  • Route3
    • N-methyl-4-(4-nitrophenoxy)picolinamide  Sorafenib Impurity|CS-0164200
      864272-34-4
    • ~97%
    • 4-(4-Aminophenoxy)-N-methylpicolinamide Sorafenib Impurity|CS-0167173
      284462-37-9

    References

    • WO2005/82853 A1, ; Page/Page column 209 ; WO 2005/082853 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   77.24
  • LogP   1.8157
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   3

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