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Structure of 2826-24-6
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This malononitrile derivative features a 4-bromobenzylidene group that confers enhanced electron-withdrawing character and facilitates efficient coupling in cross-coupling reactions. The conjugated system enables use in synthesizing functionalized heterocycles and advanced organic materials under standard conditions.
2-(4-Bromobenzylidene)malononitrile serves as a versatile building block in heterocyclic synthesis, enabling efficient access to fused pyrimidine and quinoline scaffolds via Knoevenagel condensation and subsequent cyclization. Its bromo-substituted aryl group facilitates downstream palladium-catalyzed cross-coupling reactions, while the dual nitrile groups provide high reactivity in nucleophilic addition and cycloaddition processes. The compound exhibits excellent bench stability and is readily purified by recrystallization, making it well-suited for scalable medicinal chemistry campaigns and process development.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H311-H331
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P405-P501
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Lot numbers can be found on the outside label of a product: