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CS-W001157 4
Total: USD 88.00

5-Methyl-1-indanone

  • CAS No. 4593-38-8

  • Cat. No. CS-W004332
  • Purity≥98%
  • MDL No.MFCD00032996

*For research and further manufacturing use only, not for direct human use.

5-Methyl-1-indanone|CS-W004332

Structure of 4593-38-8

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General Information

  • CAS No. 4593-38-8
  • Cat. No. CS-W004332
  • Purity ≥98%
  • MDL No. MFCD00032996
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀O
  • Molecular Weight None
  • Synonym(s) 5-Methylindanone
  • SMILES CC1=CC(CCC2=O)=C2C=C1

Description

5-Methyl-1-indanone is a bench-stable, electron-rich ketone featuring a fused bicyclic structure that enhances its utility in synthetic organic chemistry. This indanone derivative integrates readily into cascade reactions and serves as a key scaffold for pharmaceutical intermediates due to its predictable reactivity and steric profile.

Application

5-Methyl-1-indanone serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted indanone scaffolds through electrophilic and nucleophilic transformations. Its bench-stable ketone functionality tolerates a range of reaction conditions, facilitating downstream modifications such as enolate alkylation, reduction, and coupling reactions. This compound functions effectively in the synthesis of bioactive heterocycles and pharmaceutical intermediates due to its predictable reactivity and compatibility with standard purification methods.

Synthesis

  • Route1
    • null|null
      201230-82-2
    • Trimethyl-m-Tolylethynyl-silane|CS-0772149
      40230-90-8
    • ~74%
    • In-stock
      5-Methyl-1-indanone|CS-W004332
      4593-38-8

    References

    • Takeuchi, Ryo; Yasue, Hiroyuki Journal of Organic Chemistry, 1993 , vol. 58, # 20 p. 5386 - 5392
  • Route2
    • 3-(3-Methylphenyl)propionic acid Cinacalcet Impurity|CS-0214137
      3751-48-2
    • ~49%
    • In-stock
      5-Methyl-1-indanone|CS-W004332
      4593-38-8
    • In-stock
      7-Methyl-2,3-dihydroinden-1-one|CS-0061213
      39627-61-7

    References

    • Hillery, Paul S.; Cohen, Louis A. Journal of the American Chemical Society, 1983 , vol. 105, # 9 p. 2760 - 2770
  • Route3

    References

    • Bednarek; Zhu; Bally; Filipiak; Marcinek; Gebicki Journal of the American Chemical Society, 2001 , vol. 123, # 10 p. 2377 - 2387

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P264-P270-P280-P301+P310-P305+P351+P338-P330-P337+P313-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.12392
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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