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CS-W001157 4
Total: USD 88.00

2-Amino-N-(5-chloro-2-pyridinyl)-5-methoxybenzamide

  • CAS No. 280773-17-3

  • Cat. No. CS-M3559
  • Purity≥97%
  • MDL No.MFCD12841614
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Amino-N-(5-chloro-2-pyridinyl)-5-methoxybenzamide|CS-M3559

Structure of 280773-17-3

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Description

This pyridine-linked amide integrates a 5-chloro-2-pyridinyl group with a methoxy-substituted benzamide scaffold, delivering enhanced solubility and metabolic stability. The amino functionality enables direct conjugation in bioconjugation workflows, while the electron-deficient pyridine ring facilitates targeted interactions in kinase inhibitor design.

Application

2-Amino-N-(5-chloro-2-pyridinyl)-5-methoxybenzamide serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard amide coupling and Suzuki-Miyaura cross-coupling reactions. Its ortho-amino and methoxy functionalities offer complementary sites for functionalization, while the 5-chloropyridine moiety facilitates further diversification via palladium-catalyzed transformations. The compound exhibits good bench stability and is readily purified by chromatography, supporting its use in multi-step synthetic sequences targeting kinase inhibitors and other pharmaceutical scaffolds.

General Information

  • CAS No. 280773-17-3
  • Cat. No. CS-M3559
  • Purity ≥97%
  • MDL No. MFCD12841614
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₂ClN₃O₂
  • Molecular Weight None
  • Synonym(s) 2-Amino-N-(5-chloropyridin-2-yl)-5-methoxybenzamide
  • SMILES O=C(NC1=NC=C(Cl)C=C1)C2=CC(OC)=CC=C2N

Computational Chemistry Data

  • TPSA   77.24
  • LogP   2.5781
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   3

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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