3-Amino-5-bromopyridin-2(1H)-one

Name: 3-Amino-5-bromopyridin-2(1H)-one
Brand: ChemScene
Availability: InStock
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CAS No. 98786-86-8
Cat. No. CS-W015979
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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3-Amino-5-bromopyridin-2(1H)-one|CS-W015979

Structure of 98786-86-8

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General Information

CAS No. 98786-86-8
Cat. No. CS-W015979
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₅BrN₂O
Molecular Weight 189.01
Synonym(s) 3-Amino-5-bromo-2-hydroxypyridine
SMILES O=C1C(N)=CC(Br)=CN1

Description

3-Amino-5-bromopyridin-2(1H)-one features a brominated pyridinone core with an amino group at the 3-position, enabling direct functionalization in cross-coupling and heterocycle synthesis. The molecule exhibits enhanced solubility and stability under standard conditions, facilitating use in medicinal chemistry workflows and as a building block for bioactive compounds.

Application

3-Amino-5-bromopyridin-2(1H)-one serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the amino and bromo positions. The compound exhibits good bench stability and facilitates palladium-catalyzed cross-coupling reactions, including Suzuki-Miyaura and Buchwald-Hartwig couplings. Its dual reactive handles support efficient construction of complex heterocyclic scaffolds, particularly in kinase inhibitor and CNS-targeted drug discovery programs.

Synthesis

Route1
- In-stock
  
  15862-34-7
- ~53%
- In-stock
  
  98786-86-8
References
- US2005/256137 A1, ; Page/Page column 10 ;
Route2
- In-stock
  
  6945-68-2
- ~%
- In-stock
  
  98786-86-8
References
- Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 38, # 9 p. 1036 - 1040

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 58.88
LogP 0.7196
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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3-Amino-5-bromopyridin-2(1H)-one

CAS No. 98786-86-8

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