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CS-W001157 4
Total: USD 88.00

(Iodomethyl)cyclopentane

  • CAS No. 27935-87-1

  • Cat. No. CS-0309298
  • Purity≥98%
  • MDL No.MFCD03453190

*For research and further manufacturing use only, not for direct human use.

(Iodomethyl)cyclopentane|CS-0309298

Structure of 27935-87-1

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General Information

  • CAS No. 27935-87-1
  • Cat. No. CS-0309298
  • Purity ≥98%
  • MDL No. MFCD03453190
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁I
  • Molecular Weight 210.06
  • Synonym(s) (Iodomethyl)Cyclopentane, Stab. With Copper
  • SMILES C1CCC(C1)CI

Description

(Iodomethyl)cyclopentane is a reactive alkylating agent featuring a cyclopentane ring with a pendant iodomethyl group. This structure enables efficient C–C bond formation in nucleophilic substitution reactions, particularly in synthetic routes requiring selective functionalization at the ring periphery. The compound exhibits high reactivity under mild conditions and is compatible with a range of organic transformations.

Application

(Iodomethyl)cyclopentane serves as a versatile alkylating agent in synthetic organic chemistry, enabling efficient introduction of cyclopentylmethyl groups into target molecules. Its iodide functionality facilitates nucleophilic substitution under mild conditions, offering high reactivity with amines, thiols, and carbanions. The molecule exhibits excellent bench stability and compatibility with common functional groups, making it ideal for constructing complex scaffolds in medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • F. HOFFMANN-LA ROCHE AG Patent: WO2004/52869 A1, 2004 ; Location in patent: Page 71 - 72 ; WO 2004/052869 A1
  • Route2

    References

    • Hoffman-La Roche Inc. Patent: US6610846 B1, 2003 ; US 6610846 B1
  • Route3
    • Cyclopentylmethyl methanesulfonate|CS-0969357
      73017-76-2
    • ~%
    • In-stock
      (Iodomethyl)cyclopentane|CS-0309298
      27935-87-1

    References

    • Novo Nordisk A/S Patent: US2008/139562 A1, 2008 ; Location in patent: Page/Page column 14 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS06,GHS08
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H227-H301-H304-H315-H318-H335
Precautionary Statements : P210-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P331-P362+P364-P370+P378-P403-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   2.6116
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   1

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