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CS-W001157 4
Total: USD 88.00

(4-Ethoxy-3-fluorophenyl)boronic acid

  • CAS No. 279263-10-4

  • Cat. No. CS-W017023
  • Purity≥98%
  • MDL No.MFCD04115667

*For research and further manufacturing use only, not for direct human use.

(4-Ethoxy-3-fluorophenyl)boronic acid|CS-W017023

Structure of 279263-10-4

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General Information

  • CAS No. 279263-10-4
  • Cat. No. CS-W017023
  • Purity ≥98%
  • MDL No. MFCD04115667
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀BFO₃
  • Molecular Weight 183.97
  • Synonym(s) 4-Ethoxy-3-fluorophenylboronic acid
  • SMILES CCOC1=C(F)C=C(C=C1)B(O)O

Description

This boronic acid features a fluorinated aryl ring with an ethoxy substituent, enhancing solubility and electronic modulation. The pendant boronic acid group enables efficient Suzuki-Miyaura cross-coupling under standard conditions, delivering functionalized biaryls with high fidelity.

Application

(4-Ethoxy-3-fluorophenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. The ortho-fluoro and ethoxy substituents provide enhanced stability and modulate electronic properties, improving reactivity in late-stage functionalization. Its bench-stable solid form facilitates handling, purification, and integration into multi-step syntheses of heterocyclic scaffolds and pharmaceutical intermediates.

Synthesis

  • Route1
    • null|null
      121-43-7
    • In-stock
      4-bromo-1-ethoxy-2-fluorobenzene|CS-0061636
      115467-08-8
    • ~66%
    • In-stock
      (4-Ethoxy-3-fluorophenyl)boronic acid|CS-W017023
      279263-10-4

    References

    • EP2484658 A1, ; Page/Page column 44 ;
  • Route2

    References

    • EP1731493 A1, ; Page/Page column 58 ;
  • Route3

    References

    • EP2484658 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   49.69
  • LogP   -0.0958
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   3

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