4-Chloro-1H-imidazo[4,5-c]pyridine

Name: 4-Chloro-1H-imidazo[4,5-c]pyridine
Brand: ChemScene
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CAS No. 2770-01-6
Cat. No. CS-D0825
Purity≥97%
MDL No.MFCD08689582

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4-Chloro-1H-imidazo[4,5-c]pyridine|CS-D0825

Structure of 2770-01-6

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Description

4-Chloro-1H-imidazo[4,5-c]pyridine is a heterocyclic scaffold featuring a chlorinated imidazopyridine core with high electron deficiency. This configuration enables efficient coupling in transition-metal-catalyzed reactions and facilitates integration into bioactive molecules. The compound exhibits robust stability under standard bench conditions and serves as a key building block for pharmaceutical intermediates and functional materials.

Application

4-Chloro-1H-imidazo[4,5-c]pyridine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to imidazopyridine scaffolds prevalent in kinase inhibitors and CNS-targeted therapeutics. The chloro substituent facilitates palladium-catalyzed cross-coupling reactions, including Suzuki and Buchwald–Hartwig aminations, with excellent functional group tolerance and bench stability. Its reactivity profile supports rapid diversification in lead optimization campaigns.

General Information

CAS No. 2770-01-6
Cat. No. CS-D0825
Purity ≥97%
MDL No. MFCD08689582
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄ClN₃
Molecular Weight 153.57
Synonym(s) 1H-Imidazo[4,5-c]pyridine, 4-chloro-
SMILES ClC1=NC=CC2=C1N=CN2

Computational Chemistry Data

TPSA 41.57
LogP 1.6113
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Imidazole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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4-Chloro-1H-imidazo[4,5-c]pyridine

CAS No. 2770-01-6

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