8-Bromoimidazo[1,2-a]pyridine

Name: 8-Bromoimidazo[1,2-a]pyridine
Brand: ChemScene
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CAS No. 850349-02-9
Cat. No. CS-W022561
Purity≥97%
MDL No.MFCD08706060

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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8-Bromoimidazo[1,2-a]pyridine|CS-W022561

Structure of 850349-02-9

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General Information

CAS No. 850349-02-9
Cat. No. CS-W022561
Purity ≥97%
MDL No. MFCD08706060
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅BrN₂
Molecular Weight 197.03
Synonym(s) 8-BROMO-IMIDAZO[1,2-A]PYRIDINE
SMILES C1=CN=C2[N]1C=CC=C2Br

Description

8-Bromoimidazo[1,2-a]pyridine delivers a rigid, electron-deficient heterocyclic scaffold ideal for constructing bioactive molecules. This brominated imidazopyridine integrates readily into cross-coupling reactions, enabling efficient access to functionalized pharmaceutical intermediates under standard conditions.

Application

8-Bromoimidazo[1,2-a]pyridine serves as a versatile building block in medicinal chemistry, enabling efficient construction of imidazo[1,2-a]pyridine scaffolds through palladium-catalyzed cross-coupling reactions. The bromo group provides high reactivity in Suzuki, Stille, and Negishi couplings, facilitating rapid diversification at the C8 position. Its bench-stable nature and compatibility with common functional groups make it ideal for modular synthesis of bioactive heterocycles.

Synthesis

Route1
- 107-20-0
- In-stock
  
  13534-99-1
- ~91%
- In-stock
  
  850349-02-9
References
- Bischoff, Francois; Berthelot, Didier; De Cleyn, Michel; MacDonald, Gregor; Minne, Garrett; Oehlrich, Daniel; Pieters, Serge; Surkyn, Michel; Trabanco, Andres A.; Tresadern, Gary; Van Brandt, Sven; Velter, Ingrid; Zaja, Mirko; Borghys, Herman; Masungi, Chantal; Mercken, Marc; Gijsen, Harrie J. M. Journal of Medicinal Chemistry, 2012 , vol. 55, # 21 p. 9089 - 9106,18

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 17.3
LogP 2.0968
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Imidazole compounds

Key Words

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8-Bromoimidazo[1,2-a]pyridine

CAS No. 850349-02-9

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